Mr. Burton. Dr. Megson. Dr. Megson. Mr. Chairman, members of the committee, my name is Mary Megson. I am a board-certified pediatrician, fellowship-trained in child development, a member of the American Academy of Pediatrics and on the clinical faculty at the Medical College of Virginia. I have practiced pediatrics for 22 years, and the last 15 years, I have worked only with children with developmental disabilities, which include learning disabilities, attention deficit hyperactivity disorder, mental retardation, cerebral palsy, and autism. In 1978, as a resident at Boston Floating Hospital, I learned that the incidence of autism was 1 in 10,000 children. Recent surveys have suggested an incidence in several parts of the country of between 1 in 300 and 1 in 600 children. Over the last 9 months, I have charts now in an office that I opened last June on 1,900 patients, well over 1,200 of whom have fullblown criteria for autism. I have 70 autistic children in a clinical trial and I am beginning a second clinical trial to look at treatment on these children. At the same time, the State Department of Education says there are only 1,522 children with the diagnosis of autism in the State of Virginia. Mental health and mental retardation agencies have scrambled to set up infant intervention programs and have had a hard time keeping up with the numbers of delayed infants and toddlers. I have served as an advisor for the city of Richmond and the surrounding counties as they set up these infant programs and also set up special education programs for children with autism. Now there are autistic classes in each county and several classes in several schools. There has been a very rapid rise over the last several years, The segment of children with ``regressive autism''--who develop normally and then regress usually between 18 and 24 months--has increased dramatically. This past week, I was involved in four cases of children who were perfectly normal in their development until they had their school-age shots at age 5--DPT, hepatitis vaccine, MMR. Within weeks, they were autistic. In the past, this was unheard of. In the vast majority of cases, I have discovered that one parent or another reports night blindness or other rare disorders associated with a defect in something called a G protein. G proteins are proteins inside the cell that join receptors that sit in the cell membrane. They are cellular proteins that upgrade or downgrade signals in their sensory systems all over the body that regulate touch, taste, smell, hearing, and vision. They are important also in turning on or off multiple metabolic pathways, including those for glucose, lipid, protein metabolism. They also turn on and off pathways for cell growth differentiation and survival. Close to the age of autistic regression, we are adding a second defect to the G protein--namely, pertussis toxin--which completely disrupts these G protein pathways. The opposite G protein pathways are on without the off switch. In my research, I have discovered that some children are protected if they have the lipid-soluble form of Vitamin A, that's found in natural sources. Those children, especially those who are breast-fed--get the early vaccines in spite of having the genetic defect and do fine. However, the measles/ mumps/rubella vaccine at 15 months of age depletes the body of all Vitamin A. When they get the DPT the same day or several months later, many of these children disconnect. There are several metabolic problems that I am seeing repeatedly in these children. The pathway to break down the storage form of glucose in the body is on without opposition. These children have elevated blood sugars. In the past week, I have been made aware of four cases of autistic children who developed juvenile onset diabetes. There is a 68 percent incidence of diabetes in the parents or grandparents. Lipid breakdown is turned on without opposition. I have diagnosed many 2\1/2\-year-old children with autism who have serum cholesterol of 240 and above. There is an incidence in one of three of these families of heart attack of a parent or grandparent under age 55 and diagnosed with hyperlipidemia. Of great concern, cell growth, differentiation, and survival is turned on, which leads to uncontrolled cell growth. In the first 60 families I examined, there were 62 cases of malignancies associated with the RAS oncogene. I have also discovered that the measles antibody that the body makes, once they are exposed to the measles vaccine, cross-reacts with intermediate filaments. Intermediate filaments are the glue that hold the cells that line the gut wall together, so when they get that MMR vaccine, they develop a leaky gut. Intermediate filaments are also important in areas of high stress. One of the areas of highest stress in the human body is the upper small intestine right below the stomach. They develop a chronic autoimmune disorder at that point. The loss of the cell-to-cell connection also occurs in the blood-brain barrier and in the cells that surround the bite annicul: where toxins are excreted from the body. So any toxins that they are exposed to, leak through the gut wall, and they cannot pump them out of the body. The loss of cell-to-cell connection interrupts another process in the body which is very important called aproptosis, or the ability of neighborhooding cells to get rid of abnormal cells. The MMR vaccine at 15 months precedes the DPT vaccine, which turns on uncontrolled cell growth differentiation and survival. Most families have reported cancers in parents or grandparents. The genetic defect found in 30 to 50 percent of adult cancers is a cancer gene, the RAS oncogene. This is the same defect that is the defect for congenital stationary night blindness. In Harrison's Textbook of Internal Medicine, which is the standard textbook in medical schools all across this country, it is stated that it is absolutely contraindicated to give the MMR vaccine or a measles vaccine in the face of Vitamin A deficiency. I am afraid that some of these children are facing that vaccine when they are already deficient in their Vitamin A stores, and then they cannot reconnect pathways. Most of us in our current diets have the lipid-soluble form of Vitamin A taken out. This lipid-soluble form is found in liver, kidney, milk fat and cod liver oil. In lowfat milk products, however, it is taken out, and another, water-soluble form is added which they are unable to absorb. Mr. Burton. Pardon me, Dr. Megson. You heard all those buzzers. That means that I have to run to the floor and vote or else I will be voted out of office, which I do not want to happen. Dr. Megson. OK. Mr. Burton. So if you will please bear with me, I will get over there and vote and get back just as quickly as I possibly can, because I am very interested in everything that you folks are saying, and I do want to get answers to a number of questions. We have two votes, and I will be back just as quickly as possible, so we will stand in recess--there are how many votes--I think everybody had better get a cup of coffee, because there are four votes. It is probably going to be half an hour before I get back. I apologize. We stand in recess. [Recess.] Mr. Burton. I really want to apologize to those of you who have been so patient today hearing all the debate. It must have been difficult for you, but I am sure it has also been entertaining. Would you close the doors in the back after everyone comes in? OK. We left off with Dr. Megson in a very impassioned moment of her talk. Dr. Megson. Briefly, I was saying that in the vast majority of these children, I get a history from one parent or another of a disorder associated with a defect in these major signalling proteins, the G proteins. As I approached my research, I looked through the eyes of these children and tried to figure out what their world was like. Now that I have talked with them and know what questions to ask these children, I understand how these G protein defects affect their perception. They have a severe loss of rod function in their eyes. There are four beautiful studies that have been published and out there for several years that show this. They are then left with cone function in which to see their world. Cones give us color and shape in our environment. The only situations I could imagine having only color and shape to organize my world are those ``magic eye puzzles,'' where you look beyond and back up, and then you get a box of 3D. That is the only place in their visual field where they get a 3D impression of objects. Mr. Burton. Everything else is flat? Dr. Megson. Correct. Only then, when they look at a box, like television or a computer, or a therapist who is sitting right in front of them, do they consistently hear the right words for what they are looking at. So that most of the day, they are not hearing the right words for what they are looking at, because they only have one area of their visual field where they see 3D. I have treated some adults, and one adult I am treating in Alabama calls me every week and gives me the measurement of his ``box'' as it grows, and he gets better, which is really fun. The other areas of perception and sensory perception are controlled by G protein pathways as well, and adding a second defect to these children, who on a genetic basis probably have a first defect, changes multiple sensations. Their avoidance of eye contact is an attempt to have light land off-center in the retina, where they have some rod function. So when they look away from Mom, they are actually looking at Mom. When we make them force their pupils directly in front of us, we are making them look away from us. With this form of natural Vitamin A treatment, within days, they look right at you. The other things that happen in these children--suddenly, Mom's touch starts to feel like sandpaper on their skin because of modulation of touch; common sounds sound like nails scraped on a blackboard. These are words that autistic children have given me as they have gotten better. We think these children cannot abstract, when actually, we are sinking them into the middle of an abstract painting at 18 months of age, and they are left trying to figure out if the language they are hearing is connected to what they are looking at at the same time. This defect for congenital stationary night blindness is on the short arm of the X chromosome, which explains the male-to- female ratio autism, and it affects cell membrane calcium channels that Dr. Goldberg just referred to in the hippocampus. These are the NMDA/glutamate receptors in the hippocampus. These pathways are where major pathways processing language cross from the left side of the brain to the right. The pathways then go back through the hippocampus. The frontal lobe is where attention is added, executive function, inhibition of impulse, and all social judgment. When stimulated, these NMDA receptors through their G proteins stimulate other receptors in the nucleus of the cell, right there at the hippocampus. These receptors were discovered by Ron Evans in December 1998. In the animal model, when they are blocked, the mice are unable to learn or to remember changes in their environment; they act like they have significant visual perceptual problems, and they have significant spatial learning deficits. Of great concern to me is that when the hepatitis B virus was initially isolated, the protein sequences were isolated and inserted into the gene for one of these Vitamin A receptors, RAR beta. This is the critical receptor important for plasticity and retinoid signaling in the hippocampus in this area of major pathway intersection. We will have to look at the vaccine and see if there is any defect being produced by that related to the recent increase in autistic spectrum disorders. What I am treating these children with is the natural, lipid-soluble form of Vitamin A. I am giving them their recommended daily allowance only of Vitamin A in the form of cod liver oil to bypass these blocked G protein pathways and turn on these central retinoid receptors. In a few days, a lot of these children look at me, focus, they regain eye contact, and they talk about their box of vision growing. After 2 months on this Vitamin A treatment, I give them a single dose of a medicine called bethanechol, which stimulates pathways in the parasympathetic system in the gut. What I have discovered is that there are nerve receptors in the gut called acetylcholine receptors, or muscarinic receptors which are blocked in these children. This medication mimics acetylcholine. It does not cross the blood-brain barrier. I give it to these children in the office, and sometimes, 30 to 40 minutes after the initial dose, after having pathways corrected for several months of Vitamin A, when I bring them in and give them this medicine and observe them, they connect in the office. I have had children look at me, talk, act out, talk back to their mothers, and use vocabulary above their chronological age. This is a disconnect, and I have seen this again and again and again. Bill Walsh in Chicago has seen it; Woody McAinnis in Arizona has seen this change. In one child I have treated beginning last April, her IQ score has gone up 105 points, from 60 to 165. This treatment improves cognition, but these children are still really physically ill. Their Vitamin A stores are depleted, oftentimes before and if not before, at the time of the MMR vaccine, and they cannot compensate for these blocked pathways. Vitamin A has been called the anti-infective agent. It leaves them immunosuppressed when they are depleted. They lack cell-mediated immunity. Adding a second defect to this GI alpha protein blocks a very important pathway in the body where you convert retinol into something called 14-hydroxy retro-retinol. 14-HRR is needed to turn on T-cells. I give these children cod liver oil--cold water fish oil is the only natural source of 14-HRR--and the children get well. The parasympathetic nervous system which is blocked in the gut is part of what I call the peripheral nervous system. We think of the nervous system as having two major parts. The central nervous system is the brain and spinal cord. The peripheral system is divided into two parts. The sympathetic nervous system is your fight-or-flight response--everything that happens to your body when you run away from danger--you dilate your pupils, increase your heart rate, and increase your blood pressure. The parasympathetic side of the peripheral nervous system allows us to sit back, relax, focus, and digest our food. We are blocking the parasympathetic side of the nervous system, and these children are in fright or flight all the time. I have asked someone to bring these panels out so you can look at these children and see their faces. I live in a small middle-class neighborhood with 23 houses. I recently counted 30 children who were on stimulants for attention deficit hyperactivity disorder. One week ago, my oldest son, who is gifted but dyslexic, had 12 neighborhood friends over for dinner. As I looked around the table, all of these children but one had dilated pupils. After 2\1/2\ months of taking his recommended daily allowance of Vitamin A and D in cod liver oil, my son announced: ``I can read now. The letters do not jump around the page anymore.'' He can focus, and his handwriting has improved dramatically. In a survey in his private high school for dyslexic students who are bright enough to go to college, 68 out of 70 of those children reported night blindness. They see headlights like starbursts, and they get a whiteout when their picture is taken. I think we are staring a national disaster in the face which is affecting thousands of American children. The children with autism, ADD, dyslexia are lucky in a way, because they are identified. There are many other children out there who are not identified and who have just been disconnected. We must direct all of our resources and efforts to establish multidisciplinary centers to treat these children. Insurance companies should pay for evaluations, both medical and psychiatric, and treatment. For over a year, I have been paying for speech therapy for these children. They are able to talk, but they do not know what to do with their mouths. I have had 10-year-olds wake up and talk. Insurance companies do not pay for rehabilitative services for these children. These children are physically ill, immunosuppressed, have a chronic autoimmune disorder affecting multiple organ systems. We must get funding to look at the etiology of autism and identify these children prior to autistic regression and prevent this disorder. Implementing vaccine policies which are safe for all children should be our first priority. Mothers from all over the country have brought pictures of their autistic children to Washington this weekend. Most of these children were born normal and lost to ``autistic regression.'' Look into their eyes, and you will hear their silence. Mr. Burton. Thank you very much. We are going to read the text of your comments very thoroughly. Dr. Megson. Thanks.
Autistic people have fought the inclusion of ABA in therapy for us since before Autism Speaks, and other non-Autistic-led autism organizations, started lobbying legislation to get it covered by insurances and Medicaid.
ABA is a myth originally sold to parents that it would keep their Autistic child out of an institution. Today, parents are told that with early intervention therapy their child will either be less Autistic or no longer Autistic by elementary school, and can be mainstreamed in typical education classes. ABA is very expensive to pay out of pocket. Essentially, Autism Speaks has justified the big price tag up front will offset the overall burden on resources for an Autistic’s lifetime. The recommendation for this therapy is 40 hours a week for children and toddlers.
The original study that showed the success rate of ABA to be at 50% has never been replicated. In fact, the study of ABA by United States Department of Defense was denounced as a failure. Not just once, but multiple times. Simply stated: ABA doesn’t work. In study after repeated study: ABA (conversion therapy) doesn’t work.
What more recent studies do show: Autistics who experienced ABA therapy are at high risk to develop PTSD and other lifelong trauma-related conditions. Historically, the autism organizations promoting ABA as a cure or solution have silenced Autistic advocates’ opposition. ABA is also known as gay conversion therapy.
The ‘cure’ for Autistics not born yet is the prevention of birth.
The ‘cure’ is a choice to terminate a pregnancy based on ‘autism risk.’ The cure is abortion. This is the same ‘cure’ society has for Down Syndrome.
This is eugenics 2021. Instead of killing Autistics and disabled children in gas chambers or ‘mercy killings’ like in Aktion T4, it’ll happen at the doctor’s office, quietly, one Autistic baby at a time. Different approaches yes, but still eugenics and the extinction of an entire minority group of people.
Fact: You can’t cure Autistics from being Autistic.
Fact: You can’t recover an Autistic from being Autistic.
Fact: You can groom an Autistic to mask and hide their traits. Somewhat. … however, this comes at the expense of the Autistic child, promotes Autistic Burnout (this should not be confused with typical burnout, Autistic Burnout can kill Autistics), and places the Autistic child at high risk for PTSD and other lifelong trauma-related conditions.
[Note: Autism is NOT a disease, but a neurodevelopmental difference and disability.]
Fact: Vaccines Do Not Cause Autism.