Archived | Complex Genetics Of Autism Revealed | Circa June 13, 2011 #AutisticHistory

Complex Genetics Of Autism Revealed

13 June 2011

By Dr Lux Fatimathas

Appeared in BioNews

American researchers have linked hundreds of spontaneous genetic mutations to the group of psychological syndromes called autism spectrum disorders (ASDs).

Two independent studies have linked more than 100 mutated regions to ASDs. Girls with autism were shown to carry more of these mutations than boys with autism, suggesting girls may have better protection against ASDs. ‘Overall, the results have dramatically lengthened the list of genes that may have a role in causing autism. This gives us a lot more data that we can use to start to pin autism down’, said geneticist Dr Stephen Scherer from the Hospital for Sick Children in Toronto, Canada, who was not involved in the studies.

The new research suggests spontaneous genetic mutations – those not acquired through inheritance – are an important risk for developing autism, particularly in regions coding for genes. Researchers screened the genomes of 1,000 individuals with ASDs for spontaneous mutations and compared these to the genomes of unaffected family members. They identified genetic mutations, resulting in deletions or duplications of the genome, which may cause ASDs, in 130 different regions.

‘It is a large number and that will make it harder to develop therapies that will benefit a large fraction of patients’, said Professor Michael Wigler, from Cold Spring Harbour Laboratory, New York, who led one of the studies. ‘Given the number of genes that might cause autism, one shouldn’t expect that one treatment is going to cure them all’.

One region of the genome was linked to autism when duplicated, and is already known to cause the hyper-social disorder Williams-Beuren Syndrome when deleted: ‘…there’s clearly something there that’s highly relevant to social behaviour. The neurobiology of that region is going to be extraordinarily interesting’, said Professor Matthew State, head of the second study, which was carried out at Yale University, Connecticut.

Professor Wigler and colleagues also noted autistic girls carried more genetic deletions and duplications than autistic boys. ‘That may start to explain some of the sex biases, that boys are more vulnerable genetically’, said Dr Andy Shih, vice president of scientific affairs for the advocacy group Autism Speaks. There are four times more boys with autism than girls. These results suggest girls possess greater innate protection against the development of autism. ‘If you want to think about an approach to therapeutic intervention, perhaps the lessons to be learned are in the females’, said Professor Wigler.

Autism falls under the umbrella of autism spectrum disorders (ASDs), which cover a range of conditions. These can vary greatly between individuals and can include difficulties with social interaction and communication. Approximately 6 in every 1,000 children have an ASD, with 1 in every 1,000 presenting with autism. Although ASDs are thought to be highly heritable, the identification of specific genetic factors has proven difficult.

These studies were published in the journal Neuron.

[Note: Links below are original to the email, or article, and it’s very possible they no longer work.]

Autism linked to hundreds of spontaneous genetic mutations
Nature News |  9 June 2011
Autism shocker: Disorder linked to hundreds of mutant genes
CBS News |  9 June 2011
Solving the Autism Puzzle a Few Pieces at a Time
Neuron |  9 June 2011
Spontaneous gene mutations cause autism: studies
AFP |  9 June 2011
Studies: New clues to the genetic roots of autism
Time Healthland |  9 June 2011
Studies shine light on role of gene mutations in autism
Sydney Morning Herald |  10 June 2011

More With Cold Spring Harbor Laboratory


Autistic people have fought the inclusion of ABA in therapy for us since before Autism Speaks, and other non-Autistic-led autism organizations, started lobbying legislation to get it covered by insurances and Medicaid. 

ABA is a myth originally sold to parents that it would keep their Autistic child out of an institution. Today, parents are told that with early intervention therapy their child will either be less Autistic or no longer Autistic by elementary school, and can be mainstreamed in typical education classes. ABA is very expensive to pay out of pocket. Essentially, Autism Speaks has justified the big price tag up front will offset the overall burden on resources for an Autistic’s lifetime. The recommendation for this therapy is 40 hours a week for children and toddlers.

The original study that showed the success rate of ABA to be at 50% has never been replicated. In fact, the study of ABA by United States Department of Defense was denounced as a failure. Not just once, but multiple times. Simply stated: ABA doesn’t workIn study after repeated study: ABA (conversion therapy) doesn’t work. 

What more recent studies do show: Autistics who experienced ABA therapy are at high risk to develop PTSD and other lifelong trauma-related conditions. Historically, the autism organizations promoting ABA as a cure or solution have silenced Autistic advocates’ opposition. ABA is also known as gay conversion therapy.

The ‘cure’ for Autistics not born yet is the prevention of birth. 

The ‘cure’ is a choice to terminate a pregnancy based on ‘autism risk.’ The cure is abortion. This is the same ‘cure’ society has for Down Syndrome. 

This is eugenics 2021. Instead of killing Autistics and disabled children in gas chambers or ‘mercy killings’ like in Aktion T4, it’ll happen at the doctor’s office, quietly, one Autistic baby at a time. Different approaches yes, but still eugenics and the extinction of an entire minority group of people.

Fact: You can’t cure Autistics from being Autistic.

Fact: You can’t recover an Autistic from being Autistic.

Fact: You can groom an Autistic to mask and hide their traits. Somewhat. … however, this comes at the expense of the Autistic child, promotes Autistic Burnout (this should not be confused with typical burnout, Autistic Burnout can kill Autistics), and places the Autistic child at high risk for PTSD and other lifelong trauma-related conditions.

[Note: Autism is NOT a disease, but a neurodevelopmental difference and disability.]

Fact: Vaccines Do Not Cause Autism.

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