Archived | Autism Speaks: Papers Citing AGRE | Circa 2005 #NotAnAutisticAlly #AutisticHistory

Papers Citing AGRE – 2005

[Note: Links in this section go to Web Archive version of PMID]

2005

Alarcon M, Yonan AL, Gilliam TC, Cantor RM, Geschwind DH.
Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs.
PMID: 15824743
Mol Psychiatry. 2005 Apr 12 


Cantor RM, Kono N, Duvall JA, Alvarez-Retuerto A, Stone JL, Alarcon M, Nelson SF, Geschwind DH.
Replication of Autism Linkage: Fine-Mapping Peak at 17q21.
PMID: 15806440
Am J Hum Genet. 2005 Apr 1;76(6)


Bartlett CW, Gharani N, Millonig JH, Brzustowicz LM.
Three autism candidate genes: a synthesis of human genetic analysis with other disciplines.
PMID: 15749247
Int J Dev Neurosci. 2005 Apr-May;23(2-3):221-34.


Bartlett CW, Goedken R, Vieland VJ.
Effects of Updating Linkage Evidence across Subsets of Data: Reanalysis of the Autism Genetic Resource Exchange Data Set.
PMID: 15729670
Am J Hum Genet. 2005 Feb 23;76(4)

Summary by AGRE’s Researcher Liaison Vlad Kustanovich Ph.D. :

Results of autism genetic linkage studies by research groups worldwide have been difficult to interpret. In an effort to reach more conclusive results, scientists have begun using larger sample sizes in their studies. However, we have found that simply increasing the sample size of disparate collections for a single analysis may not have been as effective as we had expected.

In this new study, using family samples from the Autism Genetic Resource Exchange, researchers applied what is known as the posterier probability of linkage (PPL). This method was designed specifically to analyze multiple heterogeneous data samples to update the PPL over these samples.

The results were remarkable. Their findings now indicate a substantial likelihood of a link to chromosome 1, which previously had been overlooked. The results also provided further characterization of the possible parent-of-origin effects of the 17q11 locus.

This shift in analysis strategy enables scientists to dramatically improve overall conclusions determined in a linkage study.


McCauley JL, Li C, Jiang L, Olson LM, Crockett G, Gainer K, Folstein SE, Haines JL, Sutcliffe JS.
Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates.
PMID:15647115
BMC Med Genet. 2005 Jan 12;6(1):1

Summary by AGRE’s Researcher Liaison Vlad Kustanovich Ph.D. :

Many geneticists believe that autism is caused by an interaction of several genetic and possibly environmental factors.

A group of scientists, led by Dr. James Sutcliffe, used genetic information from AGRE families, as well as families participating in the Vanderbilt and Tuft studies, to look at the involvement of multiple genetic regions of susceptibility in contributing to specific “TRAITS” of autistic behavior. The data for these traits were extracted from the Autism Diagnostic Interview.

This approach helps researchers focus on the relationship between targeted gene regions and how their interaction may be a factor in autism. The researchers examined the genetic evidence in families with autism in combination with some additional specific “TRAITS” (low levels of language, repetitive behaviors, etc.)

These researchers discovered strong evidence that linked autism to the interaction of specific genetic regions on 19q and 17q, as well as 7q and 5q. These regions are important because they were previously identified as being important in autism.


More With AGRE



Note/Warning:

Autistic people have fought the inclusion of ABA in therapy for us since before Autism Speaks, and other non-Autistic-led autism organizations, started lobbying legislation to get it covered by insurances and Medicaid. 

ABA is a myth originally sold to parents that it would keep their Autistic child out of an institution. Today, parents are told that with early intervention therapy their child will either be less Autistic or no longer Autistic by elementary school, and can be mainstreamed in typical education classes. ABA is very expensive to pay out of pocket. Essentially, Autism Speaks has justified the big price tag up front will offset the overall burden on resources for an Autistic’s lifetime. The recommendation for this therapy is 40 hours a week for children and toddlers.

The original study that showed the success rate of ABA to be at 50% has never been replicated. In fact, the study of ABA by United States Department of Defense was denounced as a failure. Not just once, but multiple times. Simply stated: ABA doesn’t workIn study after repeated study: ABA (conversion therapy) doesn’t work. 

What more recent studies do show: Autistics who experienced ABA therapy are at high risk to develop PTSD and other lifelong trauma-related conditions. Historically, the autism organizations promoting ABA as a cure or solution have silenced Autistic advocates’ opposition. ABA is also known as gay conversion therapy.


The ‘cure’ for Autistics not born yet is the prevention of birth. 

The ‘cure’ is a choice to terminate a pregnancy based on ‘autism risk.’ The cure is abortion. This is the same ‘cure’ society has for Down Syndrome. 

This is eugenics 2021. Instead of killing Autistics and disabled children in gas chambers or ‘mercy killings’ like in Aktion T4, it’ll happen at the doctor’s office, quietly, one Autistic baby at a time. Different approaches yes, but still eugenics and the extinction of an entire minority group of people.


Fact: You can’t cure Autistics from being Autistic.

Fact: You can’t recover an Autistic from being Autistic.

Fact: You can groom an Autistic to mask and hide their traits. Somewhat. … however, this comes at the expense of the Autistic child, promotes Autistic Burnout (this should not be confused with typical burnout, Autistic Burnout can kill Autistics), and places the Autistic child at high risk for PTSD and other lifelong trauma-related conditions.


[Note: Autism is NOT a disease, but a neurodevelopmental difference and disability.]


Fact: Vaccines Do Not Cause Autism.


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